Health

Epilepsy linked to brain volume and thickness differences

Sunday, January 28, 2018

Print this page Email A Friend!


Epilepsy is associated with thickness and volume differences in the grey matter of several brain regions, according to new research led by UCL and the Keck School of Medicine of USC.

The largest-ever neuroimaging study of people with epilepsy, published in Brain, shows that epilepsy involves more widespread physical differences than previously assumed, even in types of epilepsy that are typically considered to be more benign if seizures are under control.

The brain abnormalities the researchers identified were subtle, and have not yet been implicated in any loss of function.

“We found differences in brain matter even in common epilepsies that are often considered to be comparatively benign. While we haven't yet assessed the impact of these differences, our findings suggest there's more to epilepsy than we realise, and now we need to do more research to understand the causes of these differences,” said the study's lead author, professor at UCL Institute of Neurology & Epilepsy Society Sanjay Sisodiya.

Epilepsy is a neurological disorder that affects 0.6-1.5 per cent of the global population, comprising many different syndromes and conditions, and defined by a tendency for seizures.

The study was conducted by the global ENIGMA-Epilepsy consortium — part of ENIGMA which is headquartered at the Keck School of Medicine of USC — and with pooled data from 24 research centres across Europe, North and South America, Asia and Australia. Structural brain measures were extracted from MRI brain scans of 2,149 people with epilepsy, and compared with 1,727 healthy controls. The epilepsy group was analysed together for common patterns, and divided into four subgroups to identify differences.

The team found reduced grey matter thickness in parts of the brain's outer layer (cortex) and reduced volume in subcortical brain regions in all epilepsy groups when compared to the control group. Reduced volume and thickness were associated with longer duration of epilepsy. Notably, people with epilepsy exhibited lower volume in the right thalamus -- a region which relays sensory and motor signals, and has previously only been associated with certain epilepsies — and reduced thickness in the motor cortex, which controls the body's movement.

These patterns were even present among people with idiopathic generalised epilepsies, a type of epilepsy characterised by a lack of any noticeable changes in the brain, such that typically an experienced neuroradiologist would not be able to see anything unusual in their brain scans.

“Some of the differences we found were so subtle they could only be detected due to the large sample size that provided us with very robust, detailed data,” said the study's first author, Dr Christopher Whelan.

The researchers also identified differences between the subgroups, which they say must reflect differences in underlying biology, as suggested by recent genetic studies.

“We have identified a common neuroanatomical signature of epilepsy across multiple epilepsy types. We found that structural changes are present in multiple brain regions, which informs our understanding of epilepsy as a network disorder,” Dr Whelan said.

The authors say their findings need to be followed up by longitudinal and genetic studies which could clarify the cause of the structural differences.

“From our study, we cannot tell whether the structural brain differences are caused by seizures, or perhaps an initial insult to the brain, or other consequences of seizures — nor do we know how this might progress over time. But by identifying these patterns, we are developing a neuroanatomical map showing which brain measures are key for further studies that could improve our understanding and treatment of the epilepsies,” said Professor Sisodiya.

ADVERTISEMENT




POST A COMMENT

HOUSE RULES

1. We welcome reader comments on the top stories of the day. Some comments may be republished on the website or in the newspaper � email addresses will not be published.

2. Please understand that comments are moderated and it is not always possible to publish all that have been submitted. We will, however, try to publish comments that are representative of all received.

3. We ask that comments are civil and free of libellous or hateful material. Also please stick to the topic under discussion.

4. Please do not write in block capitals since this makes your comment hard to read.

5. Please don't use the comments to advertise. However, our advertising department can be more than accommodating if emailed: advertising@jamaicaobserver.com.

6. If readers wish to report offensive comments, suggest a correction or share a story then please email: community@jamaicaobserver.com.

7. Lastly, read our Terms and Conditions and Privacy Policy



comments powered by Disqus
ADVERTISEMENT

Poll

ADVERTISEMENT
ADVERTISEMENT

Today's Cartoon

Click image to view full size editorial cartoon
ADVERTISEMENT