PAHO, Unitaid collab to advance the elimination of the transmission of Chagas disease

WASHINGTON, United States (CMC) — The Pan American Health Organization (PAHO) and Unitaid Thursday launched a five-year US$ 2.6 million partnership to scale-up regional and national efforts to eliminate mother-to-child transmission of Chagas disease.

Chagas is a neglected tropical disease endemic to countries mainly in Latin America, where it kills more people than any other parasite-borne infection. The infection is caused primarily by a blood-sucking triatomine bug, but the disease can also be transmitted from mother to child during pregnancy.

According to the World Health Organization (WHO), more than one million women of childbearing age are estimated to be infected, resulting in up to 15,000 infants born with the disease each year.

“Chagas disease holds a significant burden for more than six million people in 20 endemic countries of the Americas, many of them women and newborns,” said PAHO Director Dr Carissa Etienne.

“With this partnership, we expect to foster and accelerate investments and commitments so that every child, everywhere in the region, is born free of Chagas and the mothers living with the disease receive the treatment they need.”

The fight against Chagas disease is complicated by several factors including its multiple means of transmission, including insect bites but also from the blood of an affected person or even by consumption of contaminated food. It is also largely asymptomatic, causing affected persons to go without medical attention until developing a chronic infection, which is more difficult to treat. A lack of efficient diagnostic tools, long and difficult treatment and gaps in policy and funding pose additional challenges.

“With less than 10 per cent of people infected with Chagas disease worldwide diagnosed, and even fewer treated, Unitaid seeks to fill an enormous gap that leaves women and infants at serious risk of infection,” said Dr Philippe Duneton, executive director of Unitaid.

“This first-of-its-kind partnership between Unitaid and PAHO will ensure advances to Chagas-fighting tools can quickly become a reality for people across Latin America and beyond.”

The collaboration will leverage insights from another Unitaid-funded initiative - CUIDA Chagas, which aims to develop, test, treat and care strategies that can be replicated in different countries and contexts. The project will determine the efficacy of new shorter treatment options for chronic Chagas disease and validate ways to shorten the time needed for diagnosis.

PAHO will provide technical expertise to support the countries and institutions under the CUIDA Chagas project, and the aim is to develop better ways to interrupt mother-to-child transmission of Chagas disease and share key learnings and advances to benefit the entire region.

The PAHO and Unitaid partnership will amplify the impact of this work, ensuring that evidence directly informs policy guidance and quickly advances the wider use of more affordable point-of-care diagnostics, better counselling and treatment, and comprehensive care for women and new-borns.

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