WASHINGTON, DC, United States (AP) — Hundreds more hospitals around the country began dispensing COVID-19 shots to their workers in a rapid expansion of the US vaccination drive yesterday, while a second vaccine moved to the cusp of government authorisation.

A day after the rollout of Pfizer-BioNTech’s coronavirus shots, the Food and Drug Administration said its preliminary analysis confirmed the effectiveness and safety of the vaccine developed by Moderna and the National Institutes of Health. A panel of outside experts is expected to vote to recommend the formula on Thursday, with the Food and Drug Administration’s (FDA) green light coming soon thereafter.

The Moderna vaccine uses the same technology as Pfizer-BioNTech’s and showed similarly strong protection against COVID-19 but is easier to handle because it does not need to be kept in the deep freeze at minus 94 degrees Fahrenheit (minus 70 Celsius).

Another weapon against the outbreak can’t come soon enough: The number of dead in the US passed a staggering 300,000 on Monday, according to Johns Hopkins University, with about 2,400 deaths and over 210,000 new cases per day on average.

The devastating toll is only expected to grow in coming weeks, fuelled by holiday travel, family gatherings and lax adherence to mask-wearing and other precautions.

Packed in dry ice, shipments of the Pfizer-BioNTech vaccine began arriving yesterday at more than 400 additional hospitals and other distribution sites.

The first three million shots are being strictly rationed to front line health workers and nursing home patients, with hundreds of millions more shots needed over the coming months to protect most Americans.

The roll-out provided a measure of encouragement to exhausted doctors, nurses and other hospital staffers around the country.

Maritza Beniquez has had a front-row seat to the devastation the novel coronavirus pandemic has wrought on communities of colour in New Jersey, so she jumped at the chance to take the vaccine that is being hailed as a turning point in the long and grueling battle against the virus.

The 56-year-old emergency room nurse at Newark’s University Hospital became the first person in New Jersey to receive the vaccine on Tuesday. All recipients will get a second shot a few weeks later.

“I’m happy that in another month and a half I won’t have to be afraid to go into a room anymore. I won’t have to be afraid to perform chest compressions or be present when they’re intubating a patient,” Beniquez said. “I don’t want to be afraid anymore, and I don’t want to have that risk of taking it home to my own family and my own friends.”

Widespread acceptance of the vaccine is critical to eventually protecting enough of the US population to defeat the outbreak. But just half of Americans say they want to get vaccinated, while about a quarter don’t and the rest are unsure, according to a recent poll by The Associated Press-NORC Center for Public Health Research.

In Manchester, New Hampshire, intensive care unit nurse Heidi Kukla said she volunteered to get the shot first to help dispel fears about the vaccine’s long-term effects and the speed with which it was developed.

“I know a lot of people have reservations about getting the vaccine,” she said after getting vaccinated at Elliot Hospital. “But I can assure you that there is absolutely nothing worse than being a patient on a ventilator in an ICU anywhere in this country right now with COVID.”

The federal government is planning hundreds more shipments through the weekend.

Shots for nursing home residents won’t start in most states until next week, when some 1,100 facilities are set to begin vaccinations. Government officials project that 20 million Americans will be able to get their first shots by the end of December, and 30 million more in January.

That projection assumes swift authorisation of the Moderna vaccine, which also requires two shots for full protection. The US Government has purchased 100 million doses of the Pfizer-BioNTech vaccine and orders for 200 million doses of the Moderna serum. Assuming no manufacturing or distribution delays, that would be enough to vaccinate 150 million Americans by mid-2021.

Elsewhere around the world, the Pfizer-BioNTech vaccine is being given in Britain and Canada. And European Union regulators moved up a meeting to assess the vaccine to December 21, more than a week earlier than planned, under pressure from Germany and other countries on the continent.

In scrutinising early results of a 30,000-person study, the FDA found that Moderna’s vaccine worked just about the same as Pfizer-BioNTech’s.

The Moderna vaccine was more than 94 per cent effective overall at preventing COVID-19 illness, and 86 per cent effective in people 65 and older. The FDA uncovered no major safety problems. Side effects can include fever, fatigue and aches as the vaccine revs up the immune system.