BEIRUT, Lebanon (AP) — The Syrian Government yesterday refused a UN proposal to grant the rebel-held eastern districts of Aleppo autonomy in order to restore calm to the war-torn city.

Foreign Minister Walid al-Moallem said the state’s institutions “must be restored” across the city and the militants expelled.

At least 164 civilians have been killed since the Government renewed its assault on the besieged enclave six days ago, according to the Britain-based Syrian Observatory for Human Rights.

The UN estimates 275,000 people are trapped inside. By Saturday, the Government had damaged or destroyed every hospital in the east, according to the Syrian American Medical Society, which supports hospitals in Syria.

Yesterday, the pro-government forces advanced into parts of the strategically important Hanano district in the north-eastern parts of the city, according to state media and the observatory.

Rebels outside the city have launched two unsuccessful offensives to break the Government’s siege and have shelled the government-held western districts.

UN envoy Staffan de Mistura had proposed that the Syrian Government grant eastern Aleppo autonomy in exchange for peace, and called on the estimated 900 al-Qaeda-linked militants in the east to depart to other rebel-held territory in Syria.

But al-Moallem refused the offer in a meeting with de Mistura in Damascus yesterday. Addressing a press conference after the meeting, the foreign minister said restoring government rule was a matter of “national sovereignty”. He said Damascus would not allow the people of eastern Aleppo to be “hostages to 6,000 gunmen”.

“We agreed on the need that terrorists should get out of east Aleppo to end the suffering of the civilians in the city,” he said.

Syrian opposition forces meanwhile pressed on with their preparations to attack the Islamic State-held town of al-Bab, about 21 miles (35 kilometres) north-east of Aleppo. They are backed by Turkish ground forces operating inside Syria. Al-Moallem called the Turkish presence a “violation” of Syrian territory.

“We cannot accept to have one Turkish soldier to remain on Syria’s land,” he said.

The foreign minister called on US President-elect Donald Trump’s incoming administration to cut off support for “terrorists” in Syria and to “rein in” the states backing them, a reference to Turkey and Saudi Arabia.

President Bashar Assad said earlier this week that Trump could prove to be a “natural ally” to Damascus.

De Mistura was expected to make remarks later in the day about the meeting with the foreign minister.

The envoy warned in an interview with the UK newspaper

The Guardian earlier this week that the Government was chasing a “pyrrhic victory” in Aleppo if it does not reach a political settlement with the Opposition.

He warned the military’s approach would drive more moderate rebels into the ranks of the Islamic State group.

Earlier yesterday, at least eight children were killed when rockets struck a school in Aleppo’s government-run western quarters, the observatory said. Syrian state media said a teacher was also killed in the attack.

In the Opposition-run village of Nusaybeen, outside Damascus, activists said at least one child was killed in a presumed government air strike on a primary school.

The Government has stepped up its attacks outside Damascus in the western Ghouta region, after forcing rebels in eastern Ghouta to surrender earlier this year. The observatory says at least 30 civilians have been killed in western Ghouta over the past four days.

In Aleppo, an air strike early yesterday killed a family of six in their home in the Sakhour district in the east, according to the activist-run

Thiqa Agency. Witnesses said they smelled chlorine gas, and rescuers said the family appeared to have suffocated from toxic gas.

The allegations could not be independently verified. A UN investigative team has said the government used chlorine as a chemical weapon on at least two occasions during the five-and-a-half-year conflict.

Turkey’s Anadolu news agency meanwhile reported that a Turkish soldier was killed in an “accident” in northern Syria, without elaborating.