WASHINGTON (AP) — President Joe Biden heads to the United Kingdom on Saturday to pay his respects to Queen Elizabeth II at a time of transition in US-UK relations, as both a new royal and a new prime minister are settling in.

The hawkish approach of Prime Minister Liz Truss to Russia and China puts her on the same page as Biden. But the rise of Truss, 47, who once called the US-UK relationship “special but not exclusive,” could mark a decidedly new chapter in the trans-Atlantic partnership on trade and more.

Of high concern for Biden officials in the early going of Truss’s premiership is her backing of legislation that would shred parts of the post-Brexit trading arrangements in Northern Ireland. Analysts say the move could cause deep strain between the UK and the European Union, and undermine peace in Northern Ireland. White House press secretary Karine Jean-Pierre said the move “would not create a conducive environment” for crafting a long-awaited US-UK trade deal coveted by Truss and her Conservative Party.

“She’s signaled that she’s willing to go to the mattresses on this and that’s going to cause a rift not just between the UK and EU, but the UK and the US,” said Max Bergmann, director of the Europe program at the Center for Strategic and International Studies in Washington and a former senior State Department official in the Obama administration. “It’s one that’s going to keep the White House up at night.”

Biden and Truss had been set to meet Sunday, but the prime minister’s office said Saturday they would skip the weekend hello, opting instead for a meeting at the UN General Assembly on Wednesday, though Truss still planned to gather with other world leaders converging on London for the royal funeral. The White House confirmed the UN meeting just as the president boarded Air Force One.

The two close allies now find themselves in a period of political uncertainty on both sides of the Atlantic. Not unlike his fellow septuagenarian Biden, Charles faces questions from the public about whether his age will limit his ability to faithfully carry out the duties of the monarch.

Charles, 73, and Biden, 79, discussed global cooperation on the climate crisis last year while both attended a summit in Glasgow, Scotland. They also met at Buckingham Palace in June 2021 at a reception the queen hosted before a world leaders’ summit in Cornwall.

Truss finds herself, as Biden does, facing questions about whether she has what it takes to lift a country battered by stubborn inflation borne out of the coronavirus pandemic and exacerbated by Russia’s invasion of Ukraine unleashing chaos on the global energy market.

All the while, Britain — and the rest of Europe — is carefully watching to see what the upcoming US midterm elections will bring for the Democratic American president after he vowed upon taking office that “America is back” to being a full partner in the international community after four years of Republican Donald Trump pushing his “America First” worldview.

“It certainly is a time of change and transformation in the UK,” said Barbara A. Perry, presidential studies director at the University of Virginia’s Miller Center. She added, “What will happen to this Brexit, isolationist, getting out of NATO approach to the United Kingdom’s foreign policy, which Biden was able to overcome, at least for the last two years, by defeating Donald Trump? We don’t know what will happen in our midterms. We don’t know what will happen in 2024.”

Truss, a former accountant who was first elected to Parliament in 2010, hasn’t had much interaction with Biden. The US president called her earlier this month to congratulate her. Truss, as foreign secretary, accompanied her predecessor, Boris Johnson, on a White House visit last year.

It’s been more than 75 years since Winston Churchill declared there was a “special relationship” between the two nations, a notion that leaders on both sides have repeatedly affirmed. Still, there have been bumps along the way.

Tony Blair was derisively branded by the British tabloids as George W. Bush’s “poodle” for backing the 2003 American-led invasion of Iraq. David Cameron and Barack Obama had a “bromance,” but Obama also had his frustrations with the Brits over defense spending and the UK’s handling of Libya following the 2011 ouster of Muammar Gaddafi.

Margaret Thatcher and Ronald Reagan forged a close alliance in the midst of the Cold War, with the prime minister once telling students that the Republican president’s “really good sense of humor” helped their relationship. But there were difficulties too, such as when Thatcher and members of her Cabinet bristled at the Reagan administration’s initial neutrality in the Falklands War.

The White House wasn’t expecting Truss’s announcement in May, when she was foreign secretary, that the government would move forward with legislation that would rewrite parts of the Northern Ireland Protocol. The agreement was part of the UK’s 2020 Brexit withdrawal from the EU that was designed to avoid a hard north-south border with Ireland that might upset Northern Ireland’s fragile peace.

Now, in the first weeks of Truss’s premiership, Biden administration officials are carefully taking the measure of the new British leader. Analysts say there is some trepidation in the administration that undercutting the Northern Ireland protoco l could plunge Europe into trade turmoil at a moment when Biden is working mightily to keep the West unified in confronting Russia over its aggression against Ukraine.

“Brexit could once again become the issue — the issue that can make it difficult for all of Europe to work together at a time when it is critical for Europe to work together,” Bergmann said. “If you’re the Biden administration, this is not the time for the two of your closest partners getting into fights.”

To be certain, there were areas of friction between Biden and Johnson, who had a warm rapport with former President Donald Trump.

Biden staunchly opposed Brexit as a candidate and had expressed great concern over the future of Northern Ireland. Biden once even derided Johnson as a “physical and emotional clone” of Trump.

Johnson worked hard to overcome that impression, stressing his common ground with Biden on climate change, support for international institutions and most notably by making certain Britain was an early and generous member of the US-led alliance providing economic and military assistance to Ukraine in the aftermath of the Russian invasion.

The former prime minister also unsuccessfully pressed Biden starting days into his administration to begin negotiations on a new US-UK trade deal just as the UK regained control over its national trade policy weeks before Biden took office and following the end of a post-Brexit transition period.

But Biden largely kept focus on his domestic to-do list in the early going of his presidency—passing trillions in spending on coronavirus relief, infrastructure, and more—and put negotiations on trade deals on the back burner.

Elliot Abrams, chairman of the conservative foreign policy group Vandenberg Coalition, said that Truss needs Biden to make a new US-UK trade deal a priority. Queen Elizabeth’s funeral won’t be the setting for tough bilateral conversations, but it still marks a moment for the two leaders’ to begin taking stock of each other.

Truss, who succeeded Johnson after he was forced to resign in the face of a string of scandals, has lagged in the opinion polls. She also won her election with a smaller margin than her recent predecessors and is looking for an early win.

“I think if I were (Truss), I want recognition of the leading role Britain’s played, far more than any other country outside the United States in supporting Ukraine,” said Abrams, who served in senior national security and foreign policy roles in the Trump, George W. Bush and Reagan administrations. “And I think I’d want some positive economic message to give the British people, which could be that the free trade agreement negotiations are starting.”