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Pharma firm urged to share new ‘game-changer’ HIV drug
This is an April 30, 2020, file photo showing Gilead Sciences headquarters in Foster City, California, USA. The US government announced Tuesday June 30, 2020, that President Donald Trump had struck “an amazing deal” to buy the drug remdesivir for Americans, made by Gilead Sciences, but Health experts on Wednesday slammed the US decision to hog nearly the entire global supply.
Latest News
May 30, 2024

Pharma firm urged to share new ‘game-changer’ HIV drug

PARIS, France – More than 300 politicians, health experts and celebrities called Thursday for US pharmaceutical giant Gilead to allow generic versions of a promising new HIV drug to be produced so it can reach people in developing countries most affected by the deadly disease.

The antiretroviral drug lenacapavir could be a “real game-changer” in the fight against HIV, according to an open letter to Gilead CEO Daniel O’Day signed by a range of former world leaders, AIDS groups, activists, actors and others.

Gilead responded that it is in talks with governments and organisations about how to expand access to the drug.

Lenacapavir, which was approved for use in the United States and the European Union in 2022, only needs to be injected twice a year, making it particularly suited for people normally “excluded from high quality healthcare,” the open letter said.

“We urge Gilead to ensure that people in the Global South living with or at risk of HIV can access this groundbreaking medicine at the same time as people in the Global North can,” it said.

The signatories urged Gilead to licence the drug on the United Nations-backed Medicines Patent Pool, which would allow for cheaper generic versions to be manufactured.

Two-thirds of the 39 million people living with HIV were in Africa in 2022, according to the World Health Organization.

The letter said the “world now recalls with horror and shame that it took 10 years and 12 million lives lost before generic versions” of the first antiretroviral drugs became available worldwide.

“This innovation could help end AIDS as a public health threat by 2030 — but only if all who would benefit from it can access it.”

Because it requires just two shots a year, the drug could be particularly important for those who face stigma getting treated for HIV, including young women, LGBTQ people, sex workers and people who inject drugs, the letter said.

Among the signatories were former heads of state including Liberia’s Ellen Johnson Sirleaf and Malawi’s Joyce Banda.

UNAIDS executive director Winnie Byanyima and other humanitarian figures also signed on, as did actors including Gillian Anderson, Stephen Fry, Sharon Stone and Alan Cummings.

Another signatory, Francoise Barre-Sinoussi — the French scientist who co-discovered the HIV virus — lamented that “inequality, not science, is the greatest barrier to fighting AIDS”.

On behalf of the scientists who paved the way for such new medicine, “I implore Gilead to erase much of that inequality and make a monumental step towards ending the AIDS pandemic,” she said in a statement.

Lenacapavir, sold under the brand name Sunlenca, has been shown to reduce “viral load in patients with infections that are resistant to other treatments”, according to the European Medicines Agency.

Gilead said in a statement it was “grateful for the advocacy of all those who share our enthusiasm for the potential of lenacapavir” to be used for pre-exposure prophylaxis (PrEP) to prevent people without HIV from getting the virus.

“As we await the results of our pivotal phase 3 clinical trials which will start to read out later this year, we are in regular conversations with HIV advocates and partners, including governments and NGOs, as we work to reach our access goals,” the biotech firm said.

Gilead added that it “pioneered voluntary licensing to expand access to high-quality, low-cost medicines” in developing countries, and that more than 20 million HIV and hepatitis-B treatments were made available in such nations last year.

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